can diclofenac gel cause kidney problems

Voltarol gel should only be used during the first six months of pregnancy if considered essential by your doctor. However, well-known side effects of diclofenac treatment are gastrointestinal bleeding and cardiovascular complications [12]. The clinical significance of inhibition of renal prostaglandin synthesis. and R.G. Benylin mucus cough & cold relief tablets. If you have an injury, or a condition like arthritis, the COX in your body normally makes substances called prostaglandins. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. This medicine is not for long-term use. Renal tissue NGAL expression increased after IRI and repetitive diclofenac doses indicating tubular injury (F). When diclofenac is taken by mouth it passes into breast milk in very small amounts that are unlikely to be harmful to a nursing infant. Make sure you have discussed the use of a sun block product with your doctor. Single-dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging. Chawla L.S., Bellomo R., Bihorac A., Goldstein S.L., Siew E.D., Bagshaw S.M., Bittleman D., Cruz D., Endre Z., Fitzgerald R.L., et al. Can diclofenac gel cause problems? Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. After midline laparotomy, whole-body perfusion with ice-cold 0.9% PBS via the cannulated left ventricle resulted in a circulatory arrest. Side Effects Print Save Diclofenac Side Effects Medically reviewed by Drugs.com. The acceptance of Diclofenac is partly attributed to being a potent COX-2 inhibitor with the lowest IC50 and its rapid onset of action at lowest effective dose. Diclofenac treatment was performed via oral gavage immediately after the end of surgery (single dose) or on three consecutive days, starting immediately after surgery (repetitive treatment). Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. Reperfusion was controlled visually. If you plan to have children, talk with your doctor before using this medicine. In conclusion, diclofenac aggravated renal injury in pre-existing subclinical AKI in a dose and time-dependent manner and already a single dose can cause progression to chronic kidney disease (CKD) in this model. ; resources, F.G. and H.H. Scale bar 100 m. Apply the patch or topical system right away after removing it from the protective pouch. Damaged or non-intact skin caused by skin diseases (eg, exudative dermatitis, eczema, infection lesions), burns, or wounds (for skin patch and topical system only)Should not be used in patients with this condition. Diclofenac (Sigma-Aldrich, St. Louis, MO, USA) was dissolved in 15% polyethylenglycol 400 (PEG 400) (Sigma-Aldrich, St. Louis, MO, USA) and diluted in phosphate-buffered saline (PBS) (Th. sore throat. Choose an area free of open wounds scars, cuts, or irritation. Heart surgery (eg, coronary artery bypass graft [CABG] surgery)Should not be used to relieve pain right before or after the surgery. Diclofenac stops COX from making these prostaglandins and this reduces the inflammation and pain. PTEN loss defines a TGF-beta-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Although not all of these side effects may occur, if they do occur they may need medical attention. government site. In a previous study, a single oral dose of diclofenac caused marked nephrotoxicity involving oxidative stress and apoptosis [16]. and transmitted securely. Voltaren Gel: What It Is, Uses, Side Effects & More - Healthline Diclofenac topical solution is used to treat pain and swelling caused by osteoarthritis of the knees. The dose is referred to as 100 mg and 200 mg for convenience. Weir MR. Renal effects of nonselective NSAIDs and coxibs. Read and follow these instructions carefully. If you have diminished kidney function, you may need to avoid nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen ( Advil, Motrin) or naproxen ( Aleve, Naprosyn), but there are many other options for arthritis and kidney patients. No set time: Nsaids such as diclofenac carry the risk of GI problems. If you forget to wear or change a patch, put one on as soon as you can. Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Only take other NSAIDs if advised to by your doctor. Publishers Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Renal tissue levels of the injury marker NGAL were determined by qPCR 72 h after renal IRI and repetitive vehicle or diclofenac treatment, respectively. Don't use more than the recommended dose of gel. Effects of Nonsteroidal anti-inflammatory drugs on renal function: Focus on cyclooxygenase-2 selective inhibitors. If you're using 1.16% Voltarol gel you can apply it three to four times a day. Review of selected literature. A 69 year old male patient was a known case of hypertension and receiving tablet atenolol 25 mg once a day since 3 years. Avoid skin-to-skin contact between other people and the treated knee until the skin is completely dry. Prostaglandins cause pain, swelling and inflammation. However, 200 mg diclofenac after IRI significantly increased IFTA as a hallmark of chronic renal damage after renal IRI (Figure 2C,F,G). Acute kidney injury and maladaptive tubular repair leading to renal fibrosis. Hence, when the production of prostaglandins is blocked due to NSAIDs, it may lead to hyperkalemia, peripheral edema, increased blood pressure, weight gain and acute renal failure.[6]. Massage the gel gently into the skin. official website and that any information you provide is encrypted 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Stroke, history ofUse with caution. [2] We would like to report a case of diclofenac induced acute renal failure which was favored by the presence of co-morbid conditions namely, hypertension, falling renal function due to aging and drug interaction in a already volume decompensated patient. After paraffin embedding, 2 m sections were cut and stained with periodic acid Schiff (PAS) and Masson trichrome according to standard protocols. Bellomo R., Kellum J.A., Ronco C. Acute kidney injury. However, additional diclofenac treatment aggravated early renal injury in a dose- and time-dependent manner. Renal ischemia-reperfusion injury causes hypertension and renal perfusion impairment in the CD1 mice which promotes progressive renal fibrosis. In this study, we investigated the effects of single and repetitive oral doses of diclofenac in the setting of pre-existing subclinical AKI on the further course of AKI and on long . skin rash other than at the application site. Acute tubular injury (ATI) was studied in the unilateral IRI model and the untouched contralateral kidney served as control. Acute kidney injury and chronic kidney disease as interconnected syndromes. A single dose of 200 mg, but not 100 mg, of diclofenac caused increased renal tissue expression of the pro-fibrotic markers CTGF (Figure 2H) and col1a1 (Figure 2I) 24 h after renal IRI. Diclofenac sodium | Drugs | BNF | NICE Injuries to tendons, ligaments, muscles or joints, eg, Soft tissue rheumatism, such as frozen shoulder, tendon inflammation (tendinitis, eg, Muscle pain relief, including neck, shoulder or. and transmitted securely. pain or tenderness around the eyes and cheekbones. Acetaminophen may be considered to treat pain and inflammation during pregnancy. This medicine comes with a Medication Guide and patient instructions. Using this medicine with any of the following medicines is not recommended. On the one hand, AKI can progress to CKD [2]. Use this medicine exactly as directed by your doctor. ChildrenUse and dose must be determined by your doctor. Everything you need to know about using Voltarol gels to relieve muscle or joint pain and swelling. Safety and efficacy have not been established. Although not all of these side effects may occur, if they do occur they may need medical attention. the contents by NLM or the National Institutes of Health. Scenario: NSAIDs prescribing issues | Management | NSAIDs - prescribing It may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Diclofenac may cause redness, soreness, scaling, and peeling of the affected skin. Diclofenac treatment in the setting of sham surgery did not cause significant neutrophil infiltration compared with sham surgery with vehicle treatment (E). Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), is among the most commonly prescribed drugs and is available over the counter in some countries [9,10]. Safe and appropriate use of diclofenac in chronic kidney disease: An sharing sensitive information, make sure youre on a federal Voltarol gel may make your skin more sensitive to sunlight and increase the risk of sunburn. Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury. Diclofenac (Topical Application Route) Side Effects - Mayo Clinic Diclofenac topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. Oda S., Shirai Y., Akai S., Nakajima A., Tsuneyama K., Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice. Isoflurane was administered for anesthesia (3% induction, 12% maintenance) and butorphanol (1 mg/kg) for analgesia. ); ed.revonnah-hm@deirfliw.renniwg (W.G. Moreover, high dose NSAID use was associated with further renal function decline of up to 26% in CKD patients in a recent meta-analysis, although all NSAIDs were investigated as one group and the specific risk of diclofenac was not indicated [19]. Drodal S., Lechowicz K., Szostak B., Rosik J., Kotfis K., Machoy-Mokrzyska A., Biaecka M., Ciechanowski K., Gawroska-Szklarz B. Kidney damage from nonsteroidal anti-inflammatory drugsMyth or truth? For Voltaren 1% topical gel: After applying this medicine, do not shower, bathe, or wash the affected area for at least 1 hour. He was diagnosed with spindle cell carcinoma on left thigh and was operated for it. Huo X., Meng Q., Wang C., Wu J., Wang C., Zhu Y., Ma X., Sun H., Liu K. Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters. Blood urea nitrogen (BUN) clearance was calculated and is shown in (E). NSAIDs e.g. Check with your doctor right away if you have stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs. and R.G. [7] Diclofenac has antagonizing effect on atenolol which decreased its antihypertensive effect which further precipitates ARF. We earn a commission for products purchased through some links in this article. Kidney disease, severeShould not be used in patients with these conditions. Analysis was conducted on a Leica imaging microscope at 200-fold magnification in 10 different view fields per sample. To investigate whether a single oral dose of diclofenac administered in the setting of subclinical AKI already causes progression to chronic renal damage, unilateral IRI was performed and IFTA was determined two weeks after renal IRI and vehicle treatment or single-dose diclofenac treatment, respectively (Figure 2AG). However, the total dose should not exceed 32 g per day over all affected joints. All procedures were carried out according to guidelines from the German Society for Animal Science (Gesellschaft fr Versuchstierkunde; GV-SOLAS) and were approved by the local animal protection committee (Niedersaechsisches Landesamt fuer Verbraucherschutz und Lebensmittelsicherheit (LAVES), approval number 14/1657 and 16/2295). Severe heart failure. Apply the solution evenly on the front, back, and sides of your knee. Children younger than 6 years of ageUse and dose must be determined by your doctor. You can use them to reduce swelling and relieve pain in your muscles or joints. However, when diclofenac was administered in bilateral renal IRI, BUN clearance was significantly reduced 24 h after IRI compared with the baseline. Voltarol gels are not suitable for everyone. ; formal analysis, J.S., F.G., W.G., S.I., K.D., M.-S.J. These medications, as tablets, creams or gels, are best avoided if you have kidney disease or a kidney transplant as they can make your kidney function worse. Urinary sodium was decreased 14.1 mEq/L (normal 25-50 mEq/L) and so the osmality to 34.2 mEq/L (normal values 100-260 mEq/L). He advised people to rather go to the hospital when they feel sick instead of self-medicating and also to desist from taking pain killers from their colleagues or friends whenever they do not feel well. The following information includes only the average doses of this medicine. Journal of Pharmacology & Pharmacotherapeutics. HHS Vulnerability Disclosure, Help government site. Do not take other medicines unless they have been discussed with your doctor. Call your doctor for medical advice about side effects. Diclofenac (Topical Application Route) Description and - Mayo Clinic In the above setting, course with NSAIDs therapy i.e., tablet diclofenac 50 mg three times a day (150 mg/day) was sufficient to precipitate acute renal failure as this dose appears to impair the renal blood flow and glomerular filtration rate. * p < 0.05, ** p < 0.01, *** p < 0.001. A single oral dose of 200 mg, but not 100 mg, of diclofenac administered after mild renal IRI aggravated AKI and caused progression to chronic renal damage. Greite R., Thorenz A., Chen R., Jang M.-S., Rong S., Brownstein M.J., Tewes S., Wang L., Baniassad B., Kirsch T., et al. Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures. We use cookies to ensure that we give you the best experience on our website. ); ed.revonnah-hm@nus-im.gnaj (M.-S.J. Sham-operated mice treated with 100 mg diclofenac over three days (C) and vehicle-treated sham mice (D) served as control. PAS-stained kidney sections of IRI mice treated with vehicle (A), or repetitive doses of 100 mg diclofenac over three days (B) are shown and acute tubular injury (ATI) as a morphological sign of AKI was assessed in the outer medulla. To help you remember to use your medicine, try to get into the habit of using it at regular times. These could be symptoms of a serious kidney problem. IRI was induced by unilateral or bilateral renal pedicle clamping with a microaneurysm clip (Aesculap, Germany) for 15 min. Conceptualization, F.G. and R.G. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, After 7 days, he visited outpatient department with complaints of swelling over legs and decreased frequency of micturition. Do not apply this medicine anywhere on your body other than where your doctor tells you. In line with this finding, CXCL2, the chemoattractant for neutrophils was already upregulated after a single dose of diclofenac in a dose-dependent manner (Figure 4F). Han Y., Balkrishnan R., Hirth R.A., Hutton D.W., He K., Steffick D.E., Saran R. Assessment of prescription analgesic use in older adults with and without chronic kidney disease and outcomes. Repetitive treatment with 100 mg diclofenac over three days aggravated renal injury and caused upregulation of the pro-fibrotic marker fibronectin in the setting of subclinical AKI, but not in sham control kidneys. High doses or prolonged use of diclofenac, a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), may result in gastrointestinal complications, which, if ignored, can be fatal. Voltarol gel, uses, side effects and warnings Appropriate studies have not been performed on the relationship of age to the effects of diclofenac topical gel, patch, or solution in children and diclofenac topical system in children younger than 6 years of age. The novel finding of this study is that a single oral dose of diclofenac is sufficient to cause AKI-to-CKD transition via early upregulation of pro-fibrotic factors in pre-injured, but not healthy kidneys. A Single Oral Dose of Diclofenac Causes Transition of Experimental The following primers were used: connective tissue growth factor (CTGF) (Qiagen, #QT00096131), collagen 1 alpha 1 (col1a1) (Qiagen, #QT00162204), C-X-C motif chemokine 2 (CXCL2) (Qiagen, #QT00113253) and neutrophil gelatinase-associated lipocalin (NGAL) (Qiagen #QT00113407). You should therefore only take NSAIDs if they have been approved by your kidney doctor. Make sure to dispose of it out of the reach of children and pets. The day/night cycle was 14/10 h. All experiments were approved by the local animal protection committee of the Lower Saxony State department for animal welfare and food protection (14/1657 and 16/2295). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. https://www.mayoclinic.org/drugs-supplements/diclofenac-topical-application-route/side-effects/drg-20063434, Advertising and sponsorship opportunities, Edema (fluid retention or body swelling) or, Hyperkalemia (high potassium in the blood) or, Stomach ulcers or bleeding, history of or. and cant filter blood the way they should. Medicines can affect people in different ways. - September 07, 2017 - 3 Comments Nephrotoxic drugs can cause acute kidney injury (AKI) and analgesic nephropathy. Diclofenacis a nonsteroidal anti-inflammatory drug (NSAID). Diclofenac gel for sun damage - Solaraze. Side effects; dosage Evaluation of renal function is not feasible in the unilateral IRI model since the healthy contralateral kidney compensates for loss of renal function. The gel should be applied within the oblong area of the dosing card up to the 2 or 4 gram line (2 grams for each elbow, wrist, or hand, and 4 grams for each knee, ankle, or foot). The untouched contralateral control kidneys did not exhibit significant IFTA in all groups. Lerink L.J.S., de Kok M.J., Mulvey J.F., Le Dvdec S.E., Markovski A.A., Wst R.C.I., Alwayn I.P.J., Ploeg R.J., Schaapherder A.F.M., Bakker J.A., et al. Pt 2, Hellms S., Gueler F., Gutberlet M., Schebb N.H., Rund K., Kielstein J.T., VoChieu V., Rauhut S., Greite R., Martirosian P., et al. Manrique-Caballero C.L., del Rio-Pertuz G., Gomez H. Sepsis-associated acute kidney injury. Blood and urine tests may be needed to check for unwanted effects. A single copy of these materials may be reprinted for noncommercial personal use only. Renal dysfunctions are more prominent in geriatric population with falling renal functions. Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath. Before surgery, he was given tablet furesemide 40 mg once a day and his anti-hypertensive drug was continued. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Ungprasert P., Cheungpasitporn W., Crowson C.S., Matteson E.L. Ng L.E., Halliwell B., Wong K.P. These values of these tests when done 4 days prior to surgery were creatinine 1 mg/dl, urea of 17 mg/dl, potassium 4.6 mEq/L and sodium 141 mEq/L. Similarly, impaired baseline renal function is a relevant risk factor for the development of AKI in patients undergoing major surgery [33]. All mice had free access to drinking water and food. Repetitive doses of diclofenac after IRI significantly increased renal fibronectin expression as an early pro-fibrotic indicator after three days. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Statistical analysis was performed with GraphPad Prism (GraphPad Software, San Diego, CA USA, Version 5.0). Depending on the size of the painful area you should use a blob about the size of a penny or a two pence piece. Sham-operated mice treated with 100 mg diclofenac over three days (C) and vehicle-treated sham mice (D) served as control. BUN clearance was calculated using the following formula: Mice were sacrificed in deep general anesthesia (5% isoflurane) at 24 h, at three days and two weeks after IRI and organ retrieval was performed. All rights reserved. PDF Pain Management in Patients with Kidney Disease - Join us in fighting Age-related decline in renal blood flow in hypertensive person and volume depletion due to diuretics are further worsened by NSAIDs. Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Activation of TGF- signaling may prevent tubular cells from differentiation and regeneration after AKI [31,38]. 8600 Rockville Pike Diclofenac gel can ease the pain of muscle injury, but might it harm your kidneys? For evaluation of renal function, bilateral renal IRI was performed and urine of IRI mice treated with vehicle or a single dose of 100 mg or 200 mg diclofenac was collected in metabolic cages 24 h after IRI. According to Naranjo adverse drug reaction probability scale, diclofenac is the probable cause of this hemodynamically mediated acute renal failure. The dose equivalents between humans and mice have to be calculated based on the body weight and the species-specific pharmacokinetic features. He made this revelation earlier this morning on GTV breakfast show. Doctor Nii Odartey Lamptey who is at the Internal Medicine Department (Korle-bu Teaching Hospital) has disclosed that certain pain killers can cause the kidney to get damaged if taken regularly one of which is the Diclofenac drug. Diclofenac tablets and capsules can cause an ulcer in your stomach or gut if you take them for a long time or in big doses. Apply the solution to a clean, dry, intact skin area. It may also cause kidney problems in a newborn. The following are some of the possible side effects of Voltarol gel. Diclofenac and other non-steroidal anti-inflammatory drugs (NSAID's) cause the kidney to lose the capacity to make these protective hormones and over time, can result in progressive kidney damage. Use the enclosed dosing card to measure the appropriate dose. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy. Kidney impairment is rare if your kidney function is normal when you start to take. Use the enclosed dosing card to measure the appropriate dose. Gr-1 stain for neutrophils was performed on kidney sections of IRI mice treated with vehicle (A), or repetitive doses of 100 mg diclofenac (B) over three days are shown. The aetiology of AKI is diverse [4,5,6,7,8] and a major cause of AKI is ischemiareperfusion injury (IRI) which often occurs in post-operative settings [8]. Fibronectin-stained kidney sections of IRI mice treated with vehicle (A), or repetitive doses of 100 mg diclofenac (B) over three days are shown. Voltarol gels contain the anti-inflammatory medicine diclofenac. Damaged or non-intact skin caused by skin diseases (eg, exudative dermatitis, eczema, infection lesions), burns, or wounds (for skin patch and topical system only)Should not be used in patients with this condition. However, if you are. Paracrine regulation of the renal microcirculation. Do not use cosmetics (eg, makeup or sunscreens) or other skin care products on the same skin areas where you have applied this medicine. Clinical implications of prostaglandin and thromboxane A2 formation. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. If you are using the skin patch, try to change it at the same time and day of the week. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, acute kidney injury, chronic kidney disease, ischemiareperfusion injury, diclofenac nephrotoxicity. Stop using Voltarol. Vehicle-treated mice received 15% PEG 400 diluted with PBS. During this period of time: If you have a severe reaction from the sun, check with your doctor. This is a decision you and your doctor will make. Answer: For patients with many types of arthritis, kidney problems can indeed complicate treatment plans. It can be used for: Voltarol gels are suitable for adults and teenagers aged 14 years and over. Voltarol 12 hour joint pain relief gel contains diclofenac 2.32% . Careers, Unable to load your collection due to an error. Do not cut it into smaller pieces and do not touch the sticky surface of the patch or topical system. Expression of fibronectin in the renal cortex was determined three days after renal IRI and vehicle or repetitive diclofenac treatment. Pain affects more than 100 million people in the U.S. Pain-related costs are over $100 billion dollars in the U.S. Pain-related expenditures are more than those for diabetes, heart disease, and cancer COMBINED. Do not use a sunlamp or tanning bed or booth. If you notice any other effects, check with your healthcare professional. Do not stop using this medicine without first checking with your doctor. Total mRNA was isolated from cross-sectioned kidney slices using RNeasy Mini Kit (Qiagen, Hilden, Germany) and cDNA was subsequently synthetized with Prime Script Reverse Transcriptase reagent (Takara, Kusatsu, Japan) from DNase-treated total RNA. Using this medicine during the later part of pregnancy can harm your unborn baby. Wash your hands with soap and water before and after applying a patch or topical system. Unilateral IRI and sacrifice at day 1 was done in n = 5 mice each group. On presentation, his blood pressure was within normal range but he had marked pedal edema and decreased frequency of micturition. It may take multiple days of application for significant pain relief. It is potentially harmful in patients at risk for renal function impairment. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. and R.G. Press the patch or topical system firmly in place with your fingertips to make sure that the edges stick well. His pedal edema was also subsiding showing clinical improvement. The amount of medicine that you take depends on the strength of the medicine. Introduction. Male CD1 mice (810 weeks of age, body weight 3035 g) purchased from Charles River (Sulzfeld, Germany) were used for the experiments. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Bonventre J.V., Yang L. Cellular pathophysiology of ischemic acute kidney injury. PGE2 and PGD2 cause dilatation of the renal vascular bed along with the lowering of renal vascular resistance. Unilateral renal ischemiareperfusion injury (IRI) for 15 min was performed in male CD1 mice to induce subclinical AKI. If eye irritation persists for more than one hour, call your doctor. For osteoarthritis of the knees, ankles, or feet using Voltaren 1% gel: AdultsApply 4 grams (g) to the affected skin areas four times a day (a total of 16 g each day). Kidney problems can sometimes occur with the use of NSAID medications, including diclofenac. Imamura H., Hata J., Iida A., Manabe N., Haruma K. Evaluating the effects of diclofenac sodium and etodolac on renal hemodynamics with contrast-enhanced ultrasonography: A pilot study. Use this medicine exactly as directed by your doctor. Notably, repetitive diclofenac treatment did not cause renal injury in sham controls (Figure 3C,D,E). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Following the deranged report, his diclofenac was stopped and his investigations were repeated the following day, on day 5, day 10 and after 1 month. Acute renal failure of medical type in an elderly population. Diclofenac (Topical Application Route) Side Effects - Mayo Clinic If you continue to use this site we will assume that you are happy with it. Do not use NSAIDs such as diclofenac between 20 and 30 weeks gestation without your doctor's advice because this may cause kidney problems and low amniotic fluid volumes in the newborn.
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